Fig. 2. hab encodes the zebrafish homolog of E-cadherin. (A) Domain structure of E-cadherin, showing signal sequence, and extracellular, transmembrane and cytoplasmic domains. (B) The zebrafish amino acid sequence for each local region containing a mutation and the corresponding amino acid sequence alignments for Xenopus, chick, human and mouse. Identical residues are black; conserved residues are gray. (C) Sequence trace data showing the site of each point mutation and the corresponding change in the amino acid sequence. (D) Mutations that fall in the same domain of the protein correlate with unique traits of the phenotype. EC, extracellular domain; SIG, signal sequence; TM, transmembrane domain.