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Fig. 5. E-cadherin-specific expression in the yolk sac is independent of cis-regulatory elements in intron 2. (A-D) Whole-mount ß-gal staining of wild-type (A,C) or Ecad-In2flox (B,D, left) and Ecad-In2floxdel embryos and yolk sacs (B,D, right) at E10.5 (A,B) and E12.5 (C,D). Expression level in the yolk sac shows the same intensities in Ecad-In2flox and Ecad-In2floxdel embryos at all analyzed stages. (E) Semi-quantitative (upper panel) and real-time PCR (lower panel) of betageo (left) and Gapd transcripts (right) in yolk sacs at E10.5 and E16.5. No significant difference is observed in the level of expression between the two different strains. Scale bar: 1 mm.