Fig. 5. Three-dimensional models of the bronchial system and great arteries, illustrating the right isomeric phenotype of Cited2-null embryos at 14.5 dpc. Models viewed from ventral (A,B) or left and right sides (C,D). (A,A') Differences in topology, size, course and branching pattern of the right (yellow) and left (red) bronchial trees in the normal embryo, as well as in the arrangement of the blood vessels (brown). The Cited2-null embryo shows a symmetrical bronchial tree (B,B'), profound differences in the relationship between the bronchi and pulmonary arteries; transposition of the great arteries and interruption of the aortic arch between the origin of the left common carotid artery (CC) and the left subclavian artery (SA). (B,D) The pulmonary trunk, pulmonary arteries, ductus arteriosus, descending aorta, and left subclavian artery are shown in magenta; the aorta, coronary arteries, brachiocephalic trunk, and left common carotid artery are shown in gold. AA, ascending aorta; AR, aortic arch; DA, descending aorta; PT, pulmonary trunk; PA, pulmonary artery; DB, ductus arteriosus; CA, coronary artery; BT, brachiocephalic trunk; T, trachea; LB, lobar bronchus.