Fig. 3. Apc deficiency activates apoptosis in the crypts and slows down cell migration. (A) High magnification images of H&E-stained sections and sections immunostained for active caspase 3 from control and mutant mice (D4). Arrows indicate apoptotic cells. (B) BrdU staining at 2 and 24 hours after injection in control and mutant mice. Brackets indicate the position of the BrdU-stained cells that have migrated in the villi in 24 hours.