Fig. 11. CAMs and their associated proteins at the apex-apex junctions between the pigment and non-pigment epithelia, the apicolateral junctions between the pigment epithelia and the apicolateral junctions between the non-pigment epithelia in the ciliary body. (A) Schematic diagram of the eye. The area surrounded by the broken red line is shown in B. PE, pigment epithelia; NPE, non-pigment epithelia. (B) The localization of CAMs and their associated proteins in the ciliary body. Nectin 1, nectin 3, P-cadherin, afadin and ZO-1 localize at the puncta adherentia junctions between the pigment and non-pigment cell layers of the ciliary epithelia. Connexins localizes at the gap junctions between the pigment and non-pigment cell layers of the ciliary epithelia. Nectin 1, nectin 2 and nectin 3, afadin, ZO-1 and P-cadherin localize at the AJs between the pigment epithelia. Nectin 2, nectin 3 and afadin localize at the AJs between the non-pigment epithelia. Cadherin 11 and/or other unknown cadherins, different from P-, E- and N-cadherins, associated with - and ß-catenins are likely to localize at these AJs, as cadherin 11 and - and ß-catenins localize there. Claudins, occludin and ZO-1 localize at the TJs between the non-pigment epithelia. PE, pigment epithelia; NPE, non-pigment epithelia.