Fig. 2. Adult phenotype and Raldh2 protein analysis in Raldh2^L–/– mutants. (A,B) Ventral (left) and profile (right) views of the forepaws of 2-month-old mice. Note the abnormal flexure of anterior digits (bracket) and partial fusion between digits 2, 3 and 4 (arrowheads). (C,J) Immunodetection of Raldh2 on whole-mount embryos (C,D), transverse sections at the level of the brachial spinal cord (E-H) and dissected spinal cords flattened into an `open book' configuration (I,J). Arrowheads (C,D) highlight the brachial region. 2,5, digit numbers; bp, brachial plexus; me, meningeal cells; ms, mesenchymal cells.