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Fig. 3. Effects of FGFR signaling overexpression on eye DV polarity. (A) Unilateral injection of 2 pg iFGFR1 mRNA, followed by induction with AP20187 at stage 12.5/13, partially expands the expression domains of Vax2, Pax2, Vax1b and Raldh3 in the ventral eye, and weakly represses ET and Pax6 in stage 33 Xenopus embryos. (B) Injection of 4 pg iFGFR1 mRNA upregulates Vax2, Pax2, Vax1b and Raldh3 in the dorsal eye and strongly repress ET and Pax6. (C) Schematic representation of the results shown in A and B. Increasing FGFR levels progressively expands the OS at the expense of the retina.