Fig. 6. TNotch can suppress Wingless signalling induced by the loss of function of GSK3ß/Shaggy. (A-D) Wild-type wing disc harbouring clones of cells mutant for shaggy. (A,B) Loss of shaggy function (black in A,C) leads to ectopic expression of the high threshold target of Wingless signalling Senseless (B) and ectopic elevation of Armadillo (D). (E-H) Wing discs expressing TNotch under the control of dppGal4 and containing clones of cells lacking shaggy. TNotch reduces the ectopic expression of Senseless (F) and the elevation of Armadillo (G). H is a merged colour image of E-G. The effect on Senseless is fully penetrant but that on Armadillo can be variable (A.M.A., unpublished data). Anterior is to the left and posterior to the right.