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Fig. 1. Respecification of the AP axis of the inner ear at E1.5. (A) The surgery for AP reversal. DiI crystals were spotted in the anterior region of a right otic cup before replacing a left donor otic cup. (B) Bright-field and (C) fluorescent micrographs showing DiI labeling in a transplanted otocyst 24 hours after surgery. Arrows indicate DiI labeling in the transplanted otocyst. (D,E) Similar Lfng expression patterns (arrows) in controls (D) and AP rotated otocysts (E). A, anterior; D, dorsal. Scale bar: 100 µm.