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Fig. 3. Comparison of the genomic structure of AmphiTrk and human Trk genes. (A) Exonic domain distribution of human TRKA, TRKB and TRKC. Newly generated introns in human Trk receptors are indicated by arrows. (B) Exonic domain distribution of AmphiTrk. Domains are colour coded: purple, signal peptide; green, leucine-rich domains; yellow, cys-rich clusters; blue, type C2 Ig-like domains; orange, transmembrane surrounding regions; brown, transmembrane domain; red, tyrosine-kinase domain.