Fig. 6. Secretory responsiveness develops in the absence of cholinergic innervation. Sweating response in P60 mice after intraperitoneal injection of pilocarpine. (A,B) The glands in both control gp130^fl/fl (A) and gp130^DBHcre (B) footpads respond robustly to the pilocarpine treatment. Each pore, which appears as dark spot, represents the activity of a single gland. (C) Quantification of the number of active glands/per interdigital footpad. Data are presented as mean±s.e.m. of 12 control and six gp130^DBHcre mice. The difference between gp130^fl/fl and gp130^DBHcre mice is significant (P<0.05; unpaired, two-tailed t-test).