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Figure 4


Fig. 4. Loss of RA curtails apoptosis in perioptic mesenchyme. (A,B) Detection of phosphohistone 3 (H3P) in frontal sections of E11.5 Raldh1-/- (A) and Raldh1-/-;Raldh3-/- (B) eyes reveals no difference in cell proliferation. (C,D) TUNEL assay in frontal sections of E11.5 Raldh1-/- (C) and Raldh1-/-;Raldh3-/- (D) eyes reveals mesenchymal regions of apoptosis that are lost in the double mutant (arrows). D, dorsal; V, ventral.