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Figure 5


Fig. 5. Defects in the allantois and placental vasculature of Bmp4lacZ/S2G embryos. (A,B) Expression of Gata4 in E8.75 embryos, analyzed by whole mount in situ hybridization. Arrows indicate the distal end of the allantois that has not undergone cavitation in Bmp4lacZ/S2G embryos. (C-H) ß-Galactosidase expression in whole-mount placentas isolated from Bmp4lacZ/+ or Bmp4lacZ/S2G embryos at E9.5 (C,D), E10.5 (E,F) or E11.5 (G,H). Inset in E and F shows a sagittal section through the placenta. (I,J) Whole-mount anti-PECAM staining of placentas from E11.5 littermates.