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Figure 6


Fig. 6. Abnormal mid/hindbrain gene expression in mid-gestation Gbx2neo homozygotes. (A-P) Dorsal views of E10.5 embryos of the indicated genotype probed by whole-mount ISH for the expression of Fgf8 (A,B), Fgf17 (C,D), En2 (E,F), En1 (G,H), Otx2 (I,J), Wnt1 (K,L), Spry1 (M,N) and Spry4 (O,P). Insets in A and B show lateral views of E10.5 embryos stained for Fgf8 expression. Asterisks indicate a region of ectopic expression along the dorsal midline of the isthmus and r1.