Fig. 7. Abnormal cells with nuclear localization of ß-catenin are present in a subset of islets in 1-year-old PdxCre^late ß-cat^active mice. (A-H) Nuclear localization of ß-catenin in control (A,C,E,G) and mutant (B,D,F,H). Cells within a small subset of islets in 1-year-old PdxCre^late ß-cat^active mutant pancreata (B,D,F,H) exhibit nuclear localization of ß-catenin. These cells do not express insulin or Pdx1 (B,F; at higher magnification in D,H) seen in control islets (A,E; at higher magnification C,G). Scale bars: 50 µm in A,B,E,F; 25 µm in C,D,G,H.