Development -- Xia et al. 133 (10): 2033 Figure IG5

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Fig. 5. A comparison of ${alpha}$ 8^S50P/- ${alpha}$ 3^-/- and ${alpha}$ 8^-/- ${alpha}$ 3^-/- lenses. (A) Toluidine Blue-stained E15.5 ${alpha}$ 8^S50P/- ${alpha}$ 3^-/- and ${alpha}$ 8^-/- ${alpha}$ 3^-/- embryonic lens sections show no space between the epithelium and posterior primary fiber cells (upper panels). Photos of P21 ${alpha}$ 8^S50P/- ${alpha}$ 3^-/- and ${alpha}$ 8^-/- ${alpha}$ 3^-/- lenses display large nuclear cataracts with transparent cortex (lower panels). (B) A Toluidine Blue-stained P14 ${alpha}$ 8^S50P/- ${alpha}$ 3^-/- lens section shows degenerating inner fiber cells and normal peripheral secondary fibers. Scale bars: 50 µm for E15.5 sections; 0.5 mm for P21 lenses; 100 µm for P14 sections.