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Figure 3


Fig. 3. Coronary anomalies in Cx43-WCKO neonatal hearts. (A-D) A typical pattern of coronary deployment in control mouse hearts is characterized by single left (A) and right (C) coronary ostia, each giving rise to arteries that bifurcate into left (B) and right (D) myocardial and septal branches. (E-H) Coronary abnormalities in Cx43-WCKOs included separate right septal (E) and myocardial branch ostia (F) in one heart, an accessory coronary (AC) originating from the non-coronary sinus in another heart (G), and tunneling of the left coronary artery through the wall of the aorta (arrows, H) in a third heart. Ao, aorta; PA, pulmonary artery; LC, left coronary artery; S, septal branch; M, myocardial branch; RC, right coronary artery; RV, right ventricle. Scale bar: 100 µm.