Fig. 4. Right ventricular outflow tract (RVOT) morphology of Cx43-WCKO hearts is
grossly normal at birth. (A-C) Whole-mount images of control (A),
Cx43-WCKO (B) and Cx43fo/fo (germline Cx43-null) (C) neonatal
hearts. (D-F) Hematoxylin and Eosin-stained sections from control (D),
Cx43-WCKO (E) and Cx43fo/fo (F) neonatal hearts. The Cx43-WCKO RVOT
(arrow) appears similar to that of its littermate controls and lacks the
infundibular bulging and exaggerated trabeculation (asterisk) seen in germline
Cx43 KO hearts. P, pulmonary trunk; RVOT, right ventricular outflow tract.
Scale bar: 1 mm.