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Figure 3


Fig. 3. Inhibition of the FGF/MAPK pathway rescues the phenotype of bon mutants. (A-C) Dorsal views of embryos at 80% epiboly showing expression of sox17 in wild-type embryos (A), bon mutant embryos (B) and bon mutant embryos treated with SU5402 at 15 µM after 1000-cell stage (C). (D-F) Partial rescue of heart morphogenesis following SU5402 treatment into bon mutant embryos monitored by expression of nkx2.5 at 30 hours. The failure of heart primordia to migrate and fuse in the midline in bon mutants was partially restored by inhibition of FGF pathway (F). The genotype of the rescued embryos was verified by RFLP.