Fig. 6. Histological changes in the distal airway exposed to naphthalene. Changes in the mouse lung after exposure to naphthalene. (A) Section of a distal adult airway from a naphthalene-exposed mouse, showing abundant Clara cells (detected with antibody to Scgb1a1) and clusters of neuroendocrine (NE) cells (asterisk, stained with antibody to Cgrp). (B) A similar airway 24 hours after naphthalene exposure. Most Clara cells are lost, except for resistant cells close to NE cells and at the bronchioalveolar junctions (marked in both panels by white arrows). Images kindly provided by Adam Giangreco, Susan Reynolds and Barry Stripp (University of Pittsburgh, PA, USA).