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Figure 6


Fig. 6. BDNF increases synapse density in tectal neuron dendritic arbors by promoting synapse formation. (A) The number of PSD95-GFP-labeled postsynaptic specializations that remained stable from one observation interval to the next (0-4; 4-24; 24-48 hours) in tectal neuron dendritic arbors was similar for control, BDNF- and anti-BDNF-treated tadpoles. (B) BDNF increased the proportion of new PSD95-GFP-labeled postsynaptic specializations that are formed, an effect that primarily takes place between 4 and 24 hours after treatment. Conversely, neutralization of endogenous BDNF with anti-BDNF decreased the number of new PSD95-GFP puncta formed, most significantly between 24 and 48 hours after treatment. Bars indicate s.e.m. n=18 neurons in control, n=16 neurons in BDNF and n=12 neurons in anti-BDNF. *P≤0.05, **P≤0.005 compared with control.