Fig. 3. Negative regulators of Drosophila JAK/STAT signalling. (A) The SOCS genes are named for their chromosomal locations, and each contains an SH2 domain and a SOCS box (SB). (B) ZIMP [also called PIAS or Su(var)2-10] contains a putative chromatin binding SAP (SAF, Acinus and PIAS) domain and a zinc-containing ring finger (RF) implicated in SUMOlation. (C) A truncated STAT92E splice variant lacking an N-terminal protein:protein interaction domain results in a dominant-negative protein (Henriksen et al., 2002). Compare to Fig. 2D. (D) PTP61FC is a spliceform of ptp61F that contains a C-terminal nuclear localisation signal (N) and an Y-phosphatase domain. (E) KEN contains an N-terminal BTB/POZ (BTB) domain and three C-terminal C2H2 zinc-finger motifs. Proteins and domains shown to scale.