Fig. 8. Mode of action of Calderón. Proposed model illustrating the role of cald in Drosophila growth. Genetic and/or biochemical relationships are depicted as arrows to indicate positive regulators or as bars to represent negative regulators of targets. The TOR and InR pathways integrate the nutritional information and exert a control on cell growth, in part, regulating cald expression. Cald activity is required for the control of growth: cell size and proliferation.