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Figure 6


Fig. 6. Caudal displacement and expansion of Hox protein expression domains in Gdf11-/- mouse embryos. (A-J) Hoxc6-Hoxc10 expression in cross-sectioned E12.5 ventral spinal cords isolated from Gdf11+/+ (A,C,E,G,I) and Gdf11-/- (B,D,F,H,J) mouse embryos. Motoneurons and dorsal root ganglia are marked by Isl1 or Isl1/2 expression. (K) A diagram depicts the Hox expression domains in Gdf+/+and Gdf-/- spinal cords. Broken lines indicate the RC levels in A-J. Position of the limbs is represented in gray. Scale bar: 100 µm.