Fig. 3. The length of the cellular protrusions of macrophages depends on
dizzy. Cellular protrusions per macrophage have been measured for
the given genotypes in fixed and immunostained embryos beneath the
dorsolateral epidermis at stage 14. In dizzy mutants and in embryos
expressing ds.dizzy in macrophages the average length of cellular
protrusions per cell is about half of the length seen in wild-type
macrophages. Overexpression of dizzy (dizzyh.EP)
or of dominant-active Rap1V12 in macrophages leads to an
increase of total length per cell by a factor of about four and three,
respectively. As the protrusions of macrophages in these embryos span from
cell body to cell body, standard deviations are here based on the lengths of
individual protrusions rather than on the overall length per cell. The
increase in protrusion length depends in both cases,
dizzyh.EP and
Rap1V12, on the zygotic expression of ßPS integrin
mys. In zygotic mys mutants the length per cell is similar
to wild-type even when dizzy or dominant-active
Rap1V12 is expressed in the macrophages.