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Figure 1


Fig. 1. All three FGFR double mutants are generated. (A) Crosses designed to obtain the three possible combinations of FGFR double mutants. The Fgfr1 and Fgfr2 mutant alleles are floxed, whereas the Fgfr3 allele is a null. The embryos homozygous mutant for Fgfr2 and Fgfr3 are also heterozygous mutant for Fgfr1. Whole E12.5 control (B) and Fgfr1;Fgfr2 double mutant (C) embryos. The mutant, as well as having a smaller telencephalon (arrow), loses the frontonasal process (arrowhead).