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Figure 3


Fig. 3. Morphological phenotype of E7.5 retinas infected with RCAS:CA-ß-catenin. (A,B) Infection with RCAS:CA-ß-catenin produced abnormally protruding eyes (B) compared with RCAS:GFP-infected eyes (A). (C,D) Views from the vitreal surface of an uninfected retina (C) and a RCAS:CA-ß-catenin-infected retina (D) reveals numerous small retinal folds in D. (E,F) Hematoxylin and eosin (H&E) staining of sections from control RCAS-infected (E) and RCAS:CA-ß-catenin-infected (F) retinas. (G-J) Examples of an RCAS-infected control central retina (G) and ciliary/iris epithelia (H), and a RCAS:CA-ß-catenin-infected retina (I,J). G-I are enlargements of boxed areas in E and F; J is from an independent animal. Note the thin and folded epithelial characteristics of the RCAS:CA-ß-catenin-infected retina. Le, lens; ON, optic nerve exit. Scale bars: 1 mm.