Fig. 3. Zebrafish Sfrps are closely related to Sfrps from other vertebrates. Phylogenic tree of the Sfrps from zebrafish (Dre), frog (Xla), mouse (Mmu) and human (Hsa). The Sfrp from sea urchin (Spu) is used as the outgroup to root the tree. The probability values from the MrBayes output are given at the nodes of the branches. The five Sfrps described in this study are labeled in blue and three previously described zebrafish Sfrps are labeled in green. Protein sequences used in the alignments are available upon request.