Fig. 3. Osx1-GFP::Cre removal of ß-catenin function affects
skeletal development. Skeletal preparations of
ß-cateninc/n (wild type) and
Osx1-GFP::Cre;ß-cateninc/n (mutant) embryos
at E14.5, E16.5 and E18.5. Higher magnifications of the fore- and hindlimbs
are presented below each embryo. White arrowheads indicate comparable levels
of hypertrophy between wild-type and mutant tibia. Arrows indicate the absence
of mineralized bone matrix in mutants when compared with wild-type embryos
(black arrowheads).