Fig. 6. Conditional stabilization of ß-catenin by Osx1-GFP::Cre affects skeletal development. Skeletal preparations of Catnb^lox(ex3)/+ (wild type) and Osx1-GFP::Cre;Catnb^lox(ex3)/+ (mutant) embryos at E14.5, E16.5 and P0. Higher magnifications of the fore- and hindlimbs are presented below each embryo. Black arrows indicate the presence of a poor Alcian blue-stained discontinuous matrix in mutants in comparison with wild-type embryos at E14.5 (black arrowheads). White arrows indicate the expansion in mineralized bone matrix observed in mutants when compared with wild-type embryos (white arrowheads).