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Figure 2


Fig. 2. Expression ofZfp488 coincides with that of differentiated oligodendrocyte markers Mbp and Plp1/DM20 in the embryonic spinal cord. In situ hybridization on transverse spinal cord sections from E12.5 (A-C), E14.5 (D-F) and E18.5 (G-I) with probes to murine Zfp488, Pdgfra, Mbp and Plp1/DM20. (A-C) At E12.5, Pdgfra is expressed in the ventral spinal cord (arrow) but Zfp488 and Mbp are not. (D-F) Expression of Zfp488, Mbp and Plp1/DM20 is initially detected at E14.5 in the ventral ventricular domain (D-F, red arrows) and Zfp488 is absent in the dorsal root ganglia (blue arrows). (G-I) At E18.5, expression of Zfp488, Mbp and Plp1/DM20 occurs in a similar distribution of cells in the ventral lateral white matter of the spinal cord (arrows).