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Figure 2


Fig. 2. ERK/MAPK activation in Map2k1-/- placentas and embryos. Expression and phosphorylation levels of MAPK1/MAPK3 and MAP2K1/MAP2K2 were evaluated by western blot analysis of total protein extracts from E9.5 (A) and E10.5 (B) wild-type and Map2k1-/- embryos and placentas. Phosphorylation of MAPK1 and MAPK3 was significantly reduced in E10.5 Map2k1-/- embryos and placentas, and remained unchanged in E9.5 Map2k1-/- embryos. A reduction was also observed in the corresponding E9.5 placentas.