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Figure 2


Fig. 2. PGC distribution in the Cx43{alpha}1 KO mouse embryo. The distribution of PGCs in Cx43{alpha}1 wild-type (+/+) and homozygous Cx43{alpha}1KO (-/-) mouse embryos from E8.5 to E11.5 was observed via GFP expression mediated by an Oct4-GFP transgene. No difference was seen in the overall distribution of GFP-expressing cells in the wild-type versus KO mouse embryos. However, at E11.5 there was a noticeable reduction in GFP fluorescence in the genital ridges of the KO mouse embryos. Scale bars: 100 µm.