Fig. 1. Evolutionary conservation of DICE1. (A) Amino acid sequence alignment of DICE1 homologs in C. elegans, human, mouse and fly. The striped boxes represent von Willebrand factor type A motifs, and the gray and white boxes are homologous and nonconserved regions, respectively. The percentages refer to identical amino acids in the human homolog and the other proteins. (B) The amino acid sequences of the human and C. elegans DICE1 homologs were compared using the Vector NTI Advance program (Invitrogen). Dark and light gray backgrounds of letters signify identical and similar amino acids, respectively.