Fig. 7. Disrupted morphology and inner structure of mitochondria in DIC-1(RNAi) muscle cells observed by fluorescence microscopy and cryo-electron microscopy. (A) The musculature of dic-1(RNAi) worms shows abnormal morphology of active mitochondria stained with Mitotracker Red. (B) The mitochondrial matrix visualized with a mitochondrial matrix-targeting sequence::GFP construct controlled by the myo-3 promoter. (C) Electron micrographs of mitochondria (enclosed by brackets) in wild-type and dic-1(RNAi) muscle cells. Scale bars: 10 µm in A; 5 µm in B; 0.2 µm in C.