Fig. 10. Two possible modes of cortical association for PAR-6.Mode 1: (gray circle and oval) one or more CDC-37 clients (indicated by `?') are required for PAR-6 to bind to a PAR-3-containing complex, perhaps through direct binding to PAR-3, in a CDC-42-independent manner. Mode 2: (open shapes) one or more CDC-37 clients act to prevent CDC-42-dependent binding of PAR-6 at the cortex. PAR-3 or a protein regulated by PAR-3 acts locally to inhibit the action of the client protein, allowing CDC-42-dependent binding of PAR-6 only in the anterior.