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Figure 4


Fig. 4. Proliferation is decreased in Ccnd1-/- cerebella during early development. (A-H) Representative BrdU (A-D) and H3-P (E-H) immunohistochemistry of cerebella from P0 (A,B,E,F) and P6 (C,D,G,H) pups sacrificed 1 hour after BrdU injection. (I) Quantification of BrdU incorporation in the anterior EGL of wild-type and Ccnd1-/- (cycD1 on figure) siblings at P0 (n=7) and P6 (n=4). *P≤0.03 when comparing between +/+ and -/- littermates. (J) Quantification of H3-P positive nuclei in the EGL at P0 (n=8, P=0.07) and P6 (n=4, P=0.22) shows a trend of decreased mitotic cells in P0 but not in P6 GNPs in the mutant.