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Fig. 1. RALDH2 mediates RA signaling at early stages of embryonic craniofacial development. (A-L) RALDH2 protein distribution (A,E,I), ß-galactosidase activity of the RARE-hsp68-lacZ transgene (B,C,F,G,J,K) and Raldh3 mRNA (D,H,L) were analyzed at successive stages (as indicated on the left) in wild-type and Raldh2-/- embryos (as indicated above). (A'-K') Transverse sections at levels indicated (black lines) in the main panels. Insets show stage-matched embryos of the alternate genotype. anr, anterior neural ridge; m, mesenchyme; ov, optic vesicle; se, surface ectoderm; te, telencephalon.