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Figure 4


Fig. 4. Epigenetic dynamics in the Kcnq1 domain during preimplantation development and comparison with imprinted X inactivation. Kcnq1ot1 and Xist RNAs are paternally expressed at the two-cell stage. X-linked genes and ubiquitously imprinted genes are monoallelically expressed and repressive histone modifications are established by implantation. Monoallelic expression of ubiquitously imprinted genes is maintained in both lineages but X-linked genes only retain imprinting in the TE lineage and undergo erasure of paternal silencing in the ICM. Placental-specific imprinted genes are still biallelically expressed in blastocysts but become imprinted and marked by allele specific histone modifications exclusively in the TE lineage after implantation. The non-coding RNA Kcnq1ot1 is labelled in black, ubiquitously imprinted genes are labelled in green, placental specific imprinted genes are labelled in purple and X linked genes are shown in grey.