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Figure 1


Fig. 1. pam-1 encodes a puromycin-sensitive aminopeptidase. Alignment of PAM-1 amino acid sequence showing conservation with mouse (GenBank AAH86798) and human (GenBank NP_006301) PSA (see also Brooks et al., 2003). Colored blocks mark amino acid identity. Overlined area denotes region of homology with 26S proteasome subunits (Constam et al., 1995). The underlined GAMEN motif is characteristic of M1 family metalloproteases and the site of two of the missense mutations A278W in pam-1(or347) and A278T in pam-1(or370) (marked with *). The boxed amino acids in the HEXXH(X)18E motif are necessary for zinc binding. The star denotes the site of deletion in pam-1(or282). The open circle denotes the position of the stop codon present in pam-1(or403), W538X, while the closed circle denotes the position of the stop codon present in pam-1(or547), Q598X.