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Figure 2


Fig. 2. Aganglionosis in the distal colon of RET S697A mice. Whole-mount AchE histochemistry of the distal intestine of wild-type (A-D) and homozygous S697A mutant newborns (E-H) at P3. Lower magnification views (A,E) and higher magnification views in the proximal colon (B,F), the middle colon (C,G) and the distal colon (D,H) are shown. Homozygous mutant mice exhibited marked reduction of enteric ganglia in the middle colon (G) and their absence in the distal colon (H). Arrowheads, cecum; asterisks, terminus of the colon; bars, 1 mm.