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Figure 4


Fig. 4. Impaired migration of the ENCCs in RET S697A mutant mice. Whole-mount in situ hybridization with riboprobe specific for RET on the developing guts in wild-type (A-C) and homozygous RET S697A mutant mice (D-F) at E11.5 (A,D), E12.5 (B,E) and E14.5 (C,F). (A'-C',D'-F') show high-power views of the front of the migrating RET positive ENCCs in A-F, respectively. Arrows, the front of the migrating ENCCs; arrowheads, cecum; asterisks, terminus of the hindgut. Scale bars: 500 µm.