Fig. 5. Cpeb knockdown results in ovarian abnormalities. (A) This follicle contained two oocytes. (B) Atretic oocytes in an undifferentiated follicle composed of a single layer of the squamous granulosa cells. (C) This atretic follicle contained an atretic oocyte with abnormal and compacted granulosa cells (compare with Fig. 2D bottom right). (D,E) These panels show ovarian cysts in the ovaries of a 4-month-old and a 12-month-old mouse, respectively. Scale bars: 20 µm in A-C; 50 µm in D; 100 µm in E.