Fig. 2. Forebrain morphogenesis summary. (A-H) Frames from animations illustrating the principal forebrain-folding movements (also see Movies 4, 5 and 6 in the supplementary material). (A-D) Dorsal view, anterior is left. (E-H) Oblique view, anterior is bottom-left and dorsal is up. (A,E) The hypothalamus moves anteriorly beneath the medial eye field during subduction. The lateral edges of the neural plate begin folding towards the midline. (B,F) Lateral neural plate folds medial, forming a neuropore, below which eye-field tissue continues to fold. (C,G) Optic-vesicle formation begins as the diencephalon converges into the neural keel and moves anteriorwards. (D,H) The meeting of lateral telencephalon at the dorsal midline completes eye-field folding and closes the neuropore. Colours are indicated in A. A, anterior; P, posterior; D, dorsal; V, ventral.