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Figure 4


Fig. 4. Proliferative defects in Bmpr1aCKO;1b+/- mice. All sections are E16.5 femurs. (A) Immunostaining for PCNA. (B) TUNEL assay reveals abundant apoptotic cells in the resting and columnar zones of mutants. (C) Quantification of the rates of proliferation (PCNA) and apoptosis (TUNEL) in wild-type and mutant littermates. Values are expressed as percent labeled cells. (D) Immunostaining for CKIs reveals increased expression of p16, p21 and p27 in mutant proliferative zones. *P<0.001.