Development -- Yoon et al. 133 (23): 4667 Figure IG5

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Fig. 5. Defects in hypertrophic differentiation in Bmpr1a^CKO mice. (A) E14.5 and (B) E16.5 distal femoral growth plates immunostained for markers of hypertrophic differentiation. In B, the length of the hypertrophic zone is demarcated by a black bar. The region of marker expression is demarcated by blue double-headed arrows. There is an increase in the overall length of the hypertrophic zone and a disproportionately enlarged zone of late hypertrophic chondrocytes in mutants at E16.5.