Development -- Yoon et al. 133 (23): 4667 Figure IG9

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Fig. 9. Expanded domain of FGFR1 expression in Bmpra1^CKO and Bmpr1a^CKO;1b^+/- growth plates. Immunofluorescence staining for FGFR1 in (A) wild-type, (B) Bmpr1a^CKO and (C) Bmpr1a^CKO;1b^+/- distal femurs at E16.5. Intense staining is restricted to the hypertrophic zone (arrow) in wild-type mice. In Bmpr1a^CKO mice, intense staining for FGFR1 persists in the expanded hypertrophic zone in (arrow), but is also seen in epiphyseal and columnar chondrocytes. A similar expansion of the domain of FGFR1 expression is observed in Bmpr1a^CKO;1b^+/- growth plates.