Fig. 8. L-mutant phenotype is dependent on activation of both JNK signaling and caspase-dependent cell death. Blocking caspase-dependent cell death and the JNK signaling pathway in the wild-type eye (ey>P35+puc) (A) have no significant effect on eye development, whereas, in the L²/+ mutant (L²/+; ey>P35+puc) it results in the strong rescue of the loss-of-ventral-eye phenotype in the eye disc (B) and adult eye (B'). (C) Graph showing more than 1.5-fold increases in the frequency of rescue of the L-mutant phenotype by blocking both caspase-dependent cell death and JNK signaling as compared with blocking either one of them alone.