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Figure 1


Fig. 1. Models of E10.5 midline germ cell death. (A) Midline expression of cell death factors (red arrows) and/or the activation of cell death factor receptors of midline germ cells may activate the extrinsic apoptotic pathway in PGCs (green). (B) Loss of survival signaling in the midline at E10.5 due to restricted expression of a survival factor (yellow arrowheads) or inactivation of a survival factor receptor in midline germ cells may activate the intrinsic apoptotic pathway.