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Figure 8


Fig. 8. Ablation of Pitx2 in splanchnic mesoderm with Mef2cAHFcre- reveals an autonomous role for Pitx2 in branchiomeric muscle development. (A-F) Lineage tracing with the Mef2c AHF cre transgenic driver (arrows) indicated that the Mef2c-marked splanchnic mesoderm lineage is reduced in the first branchial arch of Mef2c AHF cre; Pitx2 n/f conditional mutant embryos at 9.5 dpc (A,B), 11.5 dpc (C,D) and 12.0 dpc (E,F). e, eye; md, mandibular process; mx, maxillary process.